Chapter 02, Bone Matrix and Mineralization ePub (Adobe DRM) download by Francis Glorieux

Chapter 02, Bone Matrix and Mineralization

Academic Press
Publication date: September 2011
ISBN: 9780124094079
Digital Book format: ePub (Adobe DRM)

Buy ePub

List price:
$9.99
Our price:
$8.99

You save: $1.00 (10%)
GET THIS EBOOK
FOR FREE!
Join our Facebook sweepstake, share and
get 10 likes. Winners
get notified in 24H!
This chapter provides an overview on the composition of the extracellular matrix of bone and discusses the matrix mineralization, and how proteins in the matrix are thought to regulate the process. The organic matrix constitutes approximately 20%-30% by weight of bone. The organic matrix contains approximately 90% collagen (by weight) and 10% non-collagenous proteins, proteoglycans, and lipids. Plasma proteins are also present in the organic matrix. Many plasma proteins permeate bone deriving from its rich vasculature, but have little or no affinity for bone, whereas others such as ?2-HS glycoprotein (fetuin A) have a higher affinity for the matrix and/or mineral of bone. The mineralization of vertebrate bone is a remarkable melding of geological and biological processes. The location of mineral within bone extracellular matrix clearly resides both within, and between, the collagen fibrils. These distinct ultra structural compartments for the mineral phase invariably provide different spatial and chemical environments for crystal growth, affecting crystal size and orientation. Beyond the initiation of mineralization in bone, crystal growth is regulated by a subcategory of the secreted, calcium-binding phosphoprotein (SCPP) family called the small, integrin-binding ligand, N-linked glycoproteins (SIBLINGs) that includes: OPN, MEPE, BSP, DMP1 and DSPP. The need for crystal growth inhibitors in tissues destined for mineralization may not at first glance be readily apparent but the massive mineralization events that occur in bones and teeth require a significant level of SIBLING protein regulation at the organic-inorganic interface as crystals must attain tissue-specific size, shape, and orientation with the extracellular matrix.
Please sign in to review this product.
Devices:
Bone Matrix and Mineralization ePub (Adobe DRM) can be read on any device that can open ePub (Adobe DRM) files.

File Size:
2875 Kb
Language:
ENG
Copy From Text:
Enabled and unlimited.
Printing:
Enabled and unlimited.
Other books by Francis Glorieux
Chapter 11, Fetal Mineral Homeostasis ePub (Adobe DRM) download by Francis Glorieux
Fetal Mineral Homeostasis
Francis Glorieux
Academic Press, September 2011
ISBN: 9780124093973
Format: ePub
List Price: $9.99 Our price: $8.99
Chapter 07, Phosphate Homeostasis Regulatory Mechanisms ePub (Adobe DRM) download by Francis Glorieux
Phosphate Homeostasis Regulatory Mechanisms
Francis Glorieux
Academic Press, September 2011
ISBN: 9780124094017
Format: ePub
List Price: $9.99 Our price: $8.99
Chapter 04, Postnatal Bone Growth: Growth Plate Biology, Bone Formation, and Remodeling ePub (Adobe DRM) download by Francis Glorieux
Postnatal Bone Growth: Growth Plate Biology, Bone Formation, and Remodeling
Francis Glorieux
Academic Press, September 2011
ISBN: 9780124094048
Format: ePub
List Price: $9.99 Our price: $8.99