Electrostatic Considerations in Mitosis: Integrating Physics and Cell Biology in Mitosis PDF (Adobe DRM) download by L. John Gagliardi

Electrostatic Considerations in Mitosis: Integrating Physics and Cell Biology in Mitosis

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Publication date: October 2009
ISBN: 9781440173776
Digital Book format: PDF (Adobe DRM)

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Identifying the motive force is central to explaining chromosome motions during mitosis. Presently, there is no consensus on what it is. The author has proposed a minimal assumptions model for the dynamics of post-attachment chromosome motions based on nanoscale electrostatics. Given the electrical properties of tubulin and the dynamic instability of microtubules, it is possible to account for prometaphase post-attachment, metaphase, and anaphase chromosome motions within a comprehensive model. The model addresses all of the following in a unified manner:
  • Efficiency of aster and spindle assembly and the motive force for the motion of asters and forming half-spindles.
  • Chromatid pair attachment.
  • Motion of monovalently attached chromatid pairs.
  • Motion of bivalently attached chromatid pairs and chromosome congression.
  • Metaphase chromatid pair oscillations.
  • Chromatid separation and anaphase-A chromosome motion.
  • Anaphase-B pole separation.
  • An ab-initio calculation of the maximum tension force exerted by a microtubule during mitosis that falls within the experimental range.
  • Poleward force generation of chromosomes at poles with associated microtubule flux.
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