Hyaluronan in Cancer Biology PDF (Adobe DRM) download by Robert Stern

Hyaluronan in Cancer Biology

Elsevier S&T
Publication date: March 2009
ISBN: 9780080921082
Digital Book format: PDF (Adobe DRM)

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Hyaluronan biology is being recognized as an important regulator of cancer progression. Paradoxically, both hyaluronan (HA) and hyaluronidases, the enzymes that eliminate HA, have also been correlated with cancer progression. Hyaluronan, a long-chain polymer of the extracellular matrix, opens up tissue spaces through which cancer cells move and metastasize. It also confers motility upon cells through interactions of cell-surface HA with the cytoskeleton. Embryonic cells in the process of movement and proliferation use the same strategy. It is an example of how cancer cells have commandeered normal cellular processes for their own survival and spread. There are also parallels between cancer and wound healing, cancer occasionally being defined as a wound that does not heal.

The growing body of literature regarding this topic has recently progressed from describing the association of hyaluronan and hyaluronidase expression associated with different cancers, to understanding the mechanisms that drive tumor cell activation, proliferation, drug resistance, etc. No one source, however, discusses hyaluronan synthesis and catabolism, as well as the factors that regulate the balance. This book offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer.

* Offers a comprehensive summary and cutting-edge insight into Hyaluronan biology, the role of the HA receptors, the hyaluronidase enzymes that degrade HA, as well as HA synthesis enzymes and their relationship to cancer

* Chapters are written by the leading international authorities on this subject, from laboratories that focus on the investigation of hyaluronan in cancer initiation, progression, and dissemination

* Focuses on understanding the mechanisms that drive tumor cell activation, proliferation, and drug resistance
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Hyaluronan in Cancer Biology PDF (Adobe DRM) download by Robert Stern
Elsevier S&T, March 2009
ISBN: 9780080921082
EAN:  9780080921082
PDF (Adobe DRM)
List Price: $85.95 eBook price: $79.99
Hyaluronan in Cancer Biology ePub (Adobe DRM) download by Robert Stern
Academic Press, March 2009
ISBN: 9780080921082
EAN:  2370004101545
ePub (Adobe DRM)
List Price: $85.95 eBook price: $79.99
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