Home on leave from World War II, author Ed Kanewske meets the beautiful, dark-haired Margie at his friend's home. They fall in love at first sight, and the two marry shortly after Ed's return from his overseas service. Thus begins a passionate, beautiful love affair that continues to this day.
Over the course of their married life, Ed and Margie raise two children, share in family vacations, and never stop loving each other. But in later years, Margie's memory begins to falter, and she is diagnosed with Alzheimer's disease. Reluctant to part with her, Ed takes care of Margie at their home for several years. When he is no longer able to manage Margie by himself, he must have her admitted to a nursing home. Despite their separation, Ed is never far from her side and visits her daily.
Ed is determined to find ways to cope with his separation from Margie. He seeks God's help, involves himself with nursing home projects, and spends time writing. But Margie is always in his thoughts. Margie and Me is a touching and unique look at how one man learned to cope with his wife's Alzheimer's. But even more, it is a story of a lifelong love affair.