The only thing twelve-year-old Indigo Lightner really wants is to be normal. Yet, this seems very unlikely for a girl who communicates with trees, heals with her hands, and reads others thoughts and feelings by the color of light surrounding them. Her mother wants her to stop her imaginary nonsense and act normal. But because Indigo's highly sensitive nervous system has her in constant sensory overload, she has minimal control over her odd behavior, eliciting the mockery of peers, frustration of teachers, her mother's disapproval, and her own self-judgment and doubt. Until one day, an incident occurs in the middle school cafeteria, leading Indigo to discover that Dayton Smith, the teen next door, also possesses special powers.
Dayton reveals to Indigo that they are both integral players in a divine plan, devised by beings of a higher realm to save the Earth from the forces of darkness. Together, they embark on a fantastic journey, traveling on the backs of their magical Gris Gris flyers to the realm of Mictlan, where they meet other gifted children from indigenous cultures all over the globe.