Curiosity just might be the death of Mrs. Murphy and her human companion, Mary Minor "Harry" Haristeen. Small towns are like families: Everyone lives very close together... and everyone keeps secrets. Crozet, Virginia, is a typical small town—until its secrets explode into murder.

Crozet's thirty-something post-mistress, Mary Minor "Harry" Haristeen, has a tiger cat (Mrs. Murphy) and a Welsh Corgi (Tucker), a pending divorce, and a bad habit of reading postcards not addressed to her. When Crozet's citizens start turning up murdered, Harry remembers that each received a card with a tombstone on the front and the message "Wish you were here" on the back.

Intent on protecting their human friend, Mrs. Murphy and Tucker begin to scent out clues. Meanwhile, Harry is conducting her own investigation, unaware her pets are one step ahead of her. If only Mrs. Murphy could alert her somehow, Harry could uncover the culprit before the murder occurs—and before Harry finds herself on the killer's mailing list.